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DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate.

Authors: Crespi, MD  Radicella, JP  Baldi, A  Charreau, EH  Calvo, JC 
Citation: Crespi MD, etal., Mol Cell Endocrinol. 1987 Oct;53(3):221-6.
Pubmed: (View Article at PubMed) PMID:2822514

The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a whole cell extract in a phosphorylation-dependent manner. These results suggest that topoisomerase I could be a target for nuclear events induced by peptide hormone action.


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CRRD Object Information
CRRD ID: 2317068
Created: 2010-03-11
Species: All species
Last Modified: 2010-03-11
Status: ACTIVE


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