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Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear.

Authors: Osman, AA  Schrader, AD  Hawkes, AJ  Akil, O  Bergeron, A  Lustig, LR  Simmons, DD 
Citation: Osman AA, etal., Mol Cell Neurosci. 2008 Jun;38(2):153-69. Epub 2008 Mar 4.
Pubmed: (View Article at PubMed) PMID:18420419
DOI: Full-text: DOI:10.1016/j.mcn.2008.02.008

Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function. We demonstrate that these accessory molecules are expressed in the inner ear raising the possibility of a muscle-like mechanism for clustering and assembly of nAChRs in hair cells. We focused our investigations on rapsyn and RIC-3. Rapsyn interacts with the cytoplasmic loop of nAChR alpha9 subunits but not nAChR alpha10 subunits. Although rapsyn and RIC-3 increase nAChR alpha9 expression, rapsyn plays a greater role in receptor clustering while RIC-3 is important for acetylcholine-induced calcium responses. Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface.

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CRRD Object Information
CRRD ID: 2317082
Created: 2010-03-12
Species: All species
Last Modified: 2010-03-12
Status: ACTIVE



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