EGF-ERBB signalling: towards the systems level.

Authors: Citri, A  Yarden, Y 
Citation: Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
Pubmed: (View Article at PubMed) PMID:16829981
DOI: Full-text: DOI:10.1038/nrm1962

Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.

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CRRD ID: 2317988
Created: 2010-05-05
Species: All species
Last Modified: 2010-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.