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Increased S100B serum levels in dilated cardiomyopathy patients.

Authors: Mazzini, GS  Schaf, DV  Vinade, ER  Horowitz, E  Bruch, RS  Brunm, LM  Goncalves, CA  Bacal, F  Souza, DO  Portela, LV  Bordignon, S 
Citation: Mazzini GS, etal., J Card Fail. 2007 Dec;13(10):850-4.
Pubmed: (View Article at PubMed) PMID:18068619
DOI: Full-text: DOI:10.1016/j.cardfail.2007.07.009

BACKGROUND: The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease. METHODS AND RESULTS: We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426-3591]) were higher than in controls (35 pg/mL [29-55]), P < .001. S100B serum levels were higher in patients group (0.051 microg/L [0.022-0.144]) than in controls (0.017 microg/L [0.003-0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013). CONCLUSIONS: Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.


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CRRD Object Information
CRRD ID: 2324684
Created: 2010-05-10
Species: All species
Last Modified: 2010-05-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.