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Distribution of stanniocalcin 1 in rat kidney and its regulation by vitamin D3.

Authors: Ookata, K  Tojo, A  Onozato, ML  Kashiwagi, M  Honda, S  Hirose, S 
Citation: Ookata K, etal., Exp Nephrol. 2001;9(6):428-35.
Pubmed: (View Article at PubMed) PMID:11702003
DOI: Full-text: DOI:52642

Stanniocalcin is a glycoprotein hormone first described in fish as a hypocalcemic factor, and recently its mammalian counterpart has been identified. Localization of stanniocalcin 1 and its regulation of expression were determined in control and 1alpha,25-dihydroxyvitamin D3-treated rats. Immunoreactivity for stanniocalcin 1 was detected in the loop of Henle, macula densa cells, distal convoluted tubule (DCT), and cortical collecting duct (CCD), and also faintly in the medullary collecting ducts. Pre-embedding electron-microscopic immunocytochemistry revealed stanniocalcin 1 in the apical membrane of cells of loop of Henle, DCT, and principal cells of CCD. The expression of stanniocalcin 1 was increased by elevated plasma calcium via 1alpha,25-dihydroxyvitamin D3 treatment. In conclusion, stanniocalcin 1 was expressed in the apical membrane of distal nephron segments and enhanced by vitamin D3.

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CRRD Object Information
CRRD ID: 2324701
Created: 2010-05-12
Species: All species
Last Modified: 2010-05-12
Status: ACTIVE



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