Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatus.

Authors: Quaroni, A  Paul, EC 
Citation: Quaroni A and Paul EC, J Cell Sci. 1999 Mar;112 ( Pt 5):707-18.
Pubmed: (View Article at PubMed) PMID:9973605

Cytocentrin is a cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis. Cloning of its cDNA demonstrated a high degree of homology with three proteins known to specifically interact with an activated form of Ral. Herein we demonstrate that overexpression of cytocentrin inhibits assembly of the mitotic spindle without affecting polymerization or distribution of interphase microtubules. Conversely, loss of cytocentrin expression leads to formation of monopolar spindles. These results indicate that association of cytocentrin with the centrosome may be essential for a timely separation of the diplosomes. They also implicate Ral GTPases and their related pathways in the assembly and function of the mitotic apparatus.


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CRRD ID: 2324919
Created: 2010-05-14
Species: All species
Last Modified: 2010-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.