Time-course of GDNF and its receptor expression after brain injury in the rat.

Authors: Cheng, Q  Di Liberto, V  Caniglia, G  Mudo, G 
Citation: Cheng Q, etal., Neurosci Lett. 2008 Jul 4;439(1):24-9. Epub 2008 May 1.
Pubmed: (View Article at PubMed) PMID:18501516
DOI: Full-text: DOI:10.1016/j.neulet.2008.04.089

The aim of the present work was to perform, by in situ hybridization, a time-course analysis of the glial cell line-derived neurotrophic factor (GDNF) and its receptor mRNA expression in two models of brain injury in the rat: (a) excitotoxic lesion by ibotenic acid injection in the hippocampal formation; (b) mechanical lesion by needle insertion through the cerebral cortex including the white matter of the corpus callosum. The time-course analysis, ranging from 6h to 8 days, showed that the GDNF and its receptor (RET, GFRalpha-1 and GFRalpha-2) mRNA expressions were differentially up-regulated in both models of lesion. This in vivo regulation of the GDNF and its receptor mRNA expression indicates their involvement in the process of neuronal protection and regeneration occurring after brain injury.


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CRRD Object Information
CRRD ID: 2324932
Created: 2010-05-17
Species: All species
Last Modified: 2010-05-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.