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Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells.

Authors: Morales, CR  Fox, A  El-Alfy, M  Ni, X  Argraves, WS 
Citation: Morales CR, etal., Microsc Res Tech. 2009 Nov;72(11):809-15.
Pubmed: (View Article at PubMed) PMID:19484749
DOI: Full-text: DOI:10.1002/jemt.20733

Desert hedgehog (Dhh) signaling plays an essential role in the normal development of the testis and in the process of spermatogenesis. Little is known about the involvement in spermatogenesis of the prototypic member of the family, Ptc1, which acts to suppress hedgehog signaling through Smoothened (Smo). Here, we have examined the expression of Ptc1, Smo, and Dhh in mouse and rat seminiferous epithelium. Our findings demonstrate that Ptc1 and Smo are expressed by primary spermatocytes and by round and condensing spermatids whereas Dhh is expressed by Sertoli cells. The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis.


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CRRD Object Information
CRRD ID: 2324985
Created: 2010-05-18
Species: All species
Last Modified: 2010-05-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.