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Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.

Authors: Tobita, K  Kijima, H  Dowaki, S  Oida, Y  Kashiwagi, H  Ishii, M  Sugio, Y  Sekka, T  Ohtani, Y  Tanaka, M  Inokuchi, S  Makuuchi, H 
Citation: Tobita K, etal., Int J Oncol. 2002 Dec;21(6):1189-95.
Pubmed: (View Article at PubMed) PMID:12429967

Pancreatic cancer is a malignant tumor with an extremely poor prognosis. Thrombospondin-1 (TSP-1) was suggested to be a potential regulator of tumor growth and metastasis. We examined TSP-1 expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the correlation between the TSP-1 expression pattern and clinicopathological features in pancreatic cancer. TSP-1 immunoreactivity was detected in the cancer stroma. The diffusely positive and focally positive patterns of TSP-1 were found in 33 (42.9%) and 40 (51.9%) of 77 cases, respectively. The TSP-1 diffuse expression was significantly correlated with lymph node metastasis (p<0.01), neural invasion (p<0.05) and TNM stage (p<0.01). The prognostic significance of clinicopathological parameters were analyzed by univariate and multivariate analysis using the log-rank test and the Cox proportional hazards model. Based on the univariate analysis, histological differentiation (p<0.01), lymphatic invasion (p<0.01), venous invasion (p<0.05), neural invasion (p<0.01), TNM stage (p<0.01) and TSP-1 expression (p<0.01) were significant parameters. These observations suggested that TSP-1 plays important roles in cancer cell growth and metastasis of human pancreatic cancer, and that stromal TSP-1 immunoreactivity is a good prognostic predictor of patients with pancreatic cancer.


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CRRD Object Information
CRRD ID: 2325025
Created: 2010-05-19
Species: All species
Last Modified: 2010-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.