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Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma.

Authors: Ohtani, Y  Kijima, H  Dowaki, S  Kashiwagi, H  Tobita, K  Tsukui, M  Tanaka, Y  Tsuchida, T  Tokunaga, T  Yamazaki, H  Nakamura, M  Ueyama, Y  Tanaka, M  Tajima, T  Makuuchi, H 
Citation: Ohtani Y, etal., Int J Oncol. 1999 Sep;15(3):453-7.
Pubmed: (View Article at PubMed) PMID:10427124

Thrombospondin-1 (TSP1) is one of the extracellular matrix glycoproteins that affect cell adhesion, motility and growth. Based on its effects on tumors, TSP1 is thought to be a potential regulator of tumor growth and metastasis. In this study, we examined TSP1 expression in human gallbladder adenocarcinoma and its clinicopathological significance. TSP1 immunoreactivity was detected mainly in the cancer stroma and was observed infrequently in cancer cells. According to the TNM classification, 74.5% (29/39) of the T2 and T3 gallbladder cancers were TSP1-positive, while none (0/14) of the T1 cancers showed TSP1 expression (p<0.001). Lymph node metastasis and venous involvement were frequently found in the TSP1-positive cases (90.0% and 87.1%, respectively) of gallbladder adenocarcinoma (p<0.001). These observations suggested that TSP1 expression plays an important role in cancer cell growth and metastasis of human gallbladder adenocarcinomas, and that stromal TSP1 immunoreactivity is a good predictor of vascular involvement and lymph node metastasis.


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CRRD Object Information
CRRD ID: 2325029
Created: 2010-05-19
Species: All species
Last Modified: 2010-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.