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Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat.

Authors: Helyes, Z  Pozsgai, G  Borzsei, R  Nemeth, J  Bagoly, T  Mark, L  Pinter, E  Toth, G  Elekes, K  Szolcsanyi, J  Reglodi, D 
Citation: Helyes Z, etal., Peptides. 2007 Sep;28(9):1847-55. Epub 2007 Jul 7.
Pubmed: (View Article at PubMed) PMID:17698245
DOI: Full-text: DOI:10.1016/j.peptides.2007.07.001

Inhibitory actions of pituitary adenylate cyclase activating polypeptide (PACAP) have been described on cellular/vascular inflammatory components, but there are few data concerning its role in neurogenic inflammation. In this study we measured PACAP-like immunoreactivity with radioimmunoassay in the rat plasma and showed a two-fold elevation in response to systemic stimulation of capsaicin-sensitive sensory nerves by resiniferatoxin, but not after local excitation of cutaneous afferents. Neurogenic plasma extravasation in the plantar skin induced by intraplantar capsaicin or resiniferatoxin, as well as carrageenan-induced paw edema were significantly diminished by intraperitoneal PACAP-38. In summary, these results demonstrate that PACAP is released from activated capsaicin-sensitive afferents into the systemic circulation. It diminishes acute pure neurogenic and mixed-type inflammatory reactions via inhibiting pro-inflammatory mediator release and/or by acting at post-junctional targets on the vascular endothelium.

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CRRD Object Information
CRRD ID: 2325282
Created: 2010-05-28
Species: All species
Last Modified: 2010-05-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.