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Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.

Authors: Perl, AK  Dahl, U  Wilgenbus, P  Cremer, H  Semb, H  Christofori, G 
Citation: Perl AK, etal., Nat Med. 1999 Mar;5(3):286-91.
Pubmed: (View Article at PubMed) PMID:10086383
DOI: Full-text: DOI:10.1038/6502

As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient RiplTag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells.


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CRRD Object Information
CRRD ID: 2326067
Created: 2010-06-21
Species: All species
Last Modified: 2010-06-21
Status: ACTIVE


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