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Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Authors: Xiong, Yong  Liu, Yuan  Cao, Liu  Wang, Dehe  Guo, Ming  Jiang, Ao  Guo, Dong  Hu, Wenjia  Yang, Jiayi  Tang, Zhidong  Wu, Honglong  Lin, Yongquan  Zhang, Meiyuan  Zhang, Qi  Shi, Mang  Liu, Yingle  Zhou, Yu  Lan, Ke  Chen, Yu 
Citation: Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Pubmed: (View Article at PubMed) PMID:32228226
DOI: Full-text: DOI:10.1080/22221751.2020.1747363

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.

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CRRD Object Information
CRRD ID: 28912744
Created: 2020-06-10
Species: All species
Last Modified: 2020-06-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.