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Glutamine and regulation of gene expression in rat hepatocytes: the role of cell swelling.

Authors: Lavoinne, A  Meisse, D  Quillard, M  Husson, A  Renouf, S  Yassad, A 
Citation: Lavoinne A, etal., Biochimie. 1998 Oct;80(10):807-11.
Pubmed: (View Article at PubMed) PMID:9893939

Glutamine is able to regulate the expression of various genes in rat hepatocytes. This includes genes coding for proteins involved in glutamine utilization, such as argininosuccinate synthetase (ureagenesis) or phosphoenolpyruvate carboxykinase (gluconeogenesis). Moreover, glutamine is also able to stimulate the expression of genes involved in the acute-phase response, such as the alpha 2-macroglobulin gene. The effect of glutamine on the regulation of gene expression may be explained, at least in part, by the cell swelling due to its sodium-dependent transport. The physiological significance of the effect of glutamine is discussed.

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CRRD Object Information
CRRD ID: 4142787
Created: 2010-09-08
Species: All species
Last Modified: 2010-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.