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Imbalance production between interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1Ra) in bronchial asthma.

Authors: Mao, XQ  Kawai, M  Yamashita, T  Enomoto, T  Dake, Y  Sasaki, S  Kataoka, Y  Fukuzumi, T  Endo, K  Sano, H  Aoki, T  Kurimoto, F  Adra, CN  Shirakawa, T  Hopkin, JM 
Citation: Mao XQ, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):607-12.
Pubmed: (View Article at PubMed) PMID:11027520
DOI: Full-text: DOI:10.1006/bbrc.2000.3516

Genes of the IL-1 family encode three different peptides, IL-1alpha, IL-1beta, and IL-1Ra, respectively. IL-1 operates through IL-1RI, and is involved in airway inflammation in asthmatic subjects, whereas IL-1Ra appears to be a specific competitive inhibitor of IL-1. All genes are on chromosome 2q12-21 where genomewide searches have identified linkage for asthma. To test whether variants of IL-1 relate to asthma, we conducted a genetic association study in a Japanese population. We show that the A2 allele of IL1RN (encoding IL-1Ra) associates with nonatopic asthma [OR = 5.71, 95% CI: 1.63-19. 8, Pc = 0.007]. Both atopic and nonatopic asthmatics with the A2 allele had significantly lower serum IL-1Ra levels in both types of asthmatics. Peripheral blood cells from asthmatics with A2 alleles, however, produced as much IL-1 as did those with A1 homozygotes. Since Th1 and Th2 cytokines differentially regulate the ratio between IL-1beta and IL-1Ra, these findings suggest that dysregulation of IL-1beta/IL-1Ra, probably due to interaction between epithelium and immuno-competent cells in the airway, is important in asthma inflammation.


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CRRD Object Information
CRRD ID: 4143224
Created: 2010-09-20
Species: All species
Last Modified: 2010-09-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.