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Association of a lymphotoxin-alpha gene polymorphism and atopic asthma in Taiwanese children.

Authors: Huang, SC  Wu, WJ  Sun, HL  Lue, KH  Hsu, CH  Liao, PF  Ku, MS 
Citation: Huang SC, etal., Pediatr Neonatol. 2008 Apr;49(2):30-4.
Pubmed: (View Article at PubMed) PMID:18947013
DOI: Full-text: DOI:10.1016/S1875-9572(08)60008-X

BACKGROUND: The lymphotoxin-alpha (LT-alpha) gene is located on chromosome 6 (6p21.1-6p21.3) and it may regulate tumor necrosis factor (TNF) production. TNF is a potent cytokine in the airway inflammatory response. Polymorphisms of TNF-associated genes have been related to asthma. This study investigated an LT-alpha-Ncol polymorphism in the first intron of the LT-alpha gene (LT-alpha-Ncol*1 allele, as a variant type; and LT-alpha-Ncol*2 allele), which may predispose individuals to asthma and atopy. METHODS: Polymerase chain reaction-based assays were performed to determine LT-alpha-Ncol genotypes among our subjects. A genetic case control analysis was then performed on 114 atopic asthmatic and 155 non-asthmatic unrelated children. RESULTS: There was a statistically higher frequency of LT-alpha-Ncol*1 allele carriers (1/1+1/2) in the subjects with atopic asthma than in controls (OR=1.923; 95% CI = 1.061-3.484; p = 0.031). CONCLUSION: The results indicate that LT-alpha-Ncol*1 may be a risk factor for atopic asthma in Taiwanese children.


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CRRD Object Information
CRRD ID: 4143370
Created: 2010-09-22
Species: All species
Last Modified: 2010-09-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.