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Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma.

Authors: Lun, SW  Wong, CK  Ko, FW  Hui, DS  Lam, CW 
Citation: Lun SW, etal., J Clin Immunol. 2009 May;29(3):330-42. Epub 2008 Dec 6.
Pubmed: (View Article at PubMed) PMID:19067129
DOI: Full-text: DOI:10.1007/s10875-008-9269-1

BACKGROUND: We investigated the expression profile of toll-like receptors (TLRs) and TLR ligand-activated production profile of asthma-related inflammatory cytokines in asthmatic patients. The expression of TLR1-8 on monocytes, CD4+ T helper lymphocytes, CD8+ T cytotoxic lymphocytes, CD19+ B lymphocytes, and dendritic cells, and ex vivo production of cytokines from peripheral blood mononuclear cells activated by TLR ligands were measured by flow cytometry. DISCUSSION: Ex vivo productions of TNF-alpha, IL-10, and IL-1beta by TLR4 and TLR5 ligand LPS and flagellin were significantly lower in asthmatic patients (all P < 0.05). Expression of TLR4 and TLR5 was also found to be significantly lower in asthmatic patients when compared to that of control subjects (all P < 0.05). Therefore, the decreased activation of TLR4 and TLR5 in asthmatic patients might contribute to the immunopathological mechanisms of asthma by reducing the release of Th1 and anti-inflammatory cytokines.


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CRRD Object Information
CRRD ID: 4144190
Created: 2010-10-12
Species: All species
Last Modified: 2010-10-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.