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Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity.

Authors: Martin, AC  Laing, IA  Khoo, SK  Zhang, G  Rueter, K  Teoh, L  Taheri, S  Hayden, CM  Geelhoed, GC  Goldblatt, J  LeSouef, PN 
Citation: Martin AC, etal., Am J Respir Crit Care Med. 2006 Mar 15;173(6):617-22. Epub 2005 Dec 30.
Pubmed: (View Article at PubMed) PMID:16387800
DOI: Full-text: DOI:10.1164/rccm.200509-1367OC

RATIONALE: The majority of previous studies investigating asthma genetics have focused on cohorts with stable disease and have not defined mechanisms important during acute asthma. CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region polymorphism. OBJECTIVES: This study was designed to determine the influence of these polymorphisms on plasma levels of their products and clinical disease during acute asthma. We hypothesized that genotype-related differences in CD14 and CC16 production would be more marked during acute asthma and related to disease severity. METHODS: We studied 148 children on presentation with acute asthma and again in convalescence. CD14 C-159T and CC16 A38G genotypes were determined, and plasma levels of soluble CD14 (sCD14) and CC16 were measured at both times. MEASUREMENTS AND MAIN RESULTS: During acute asthma, plasma sCD14 levels were higher for the whole group (p = 0.003), but increases were only in subjects with CD14 -159TT (p = 0.003) and -159CT (p = 0.004), and not in those with -159CC. Plasma CC16 levels were also elevated acutely for the whole group (p = 0.013), but only in those with CC16 38GG (p = 0.043) and 38AG (p = 0.014), and not in those with CC16 38AA. Subjects with CD14 -159CC and CC16 38AA were more likely to have moderate or severe acute asthma. CONCLUSIONS: Plasma levels of sCD14 and CC16 were higher during acute asthma in the subjects. Those with CD14 -159CC and CC16 38AA had no change in sCD14 and CC16 levels and more severe asthma.

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CRRD Object Information
CRRD ID: 4144813
Created: 2010-10-15
Species: All species
Last Modified: 2010-10-15
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.