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Beta2-adrenoceptor polymorphisms predict response to beta2-agonists in children with acute asthma.

Authors: Martin, AC  Zhang, G  Rueter, K  Khoo, SK  Bizzintino, J  Hayden, CM  Geelhoed, GC  Goldblatt, J  Laing, IA  Le Souef, PN 
Citation: Martin AC, etal., J Asthma. 2008 Jun;45(5):383-8.
Pubmed: (View Article at PubMed) PMID:18569231
DOI: Full-text: DOI:10.1080/02770900801971792

The aim of this study was to determine the influence of single nucleotide polymorphisms in the beta(2)-adrenoceptor gene, on the response to inhaled beta(2)-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to beta(2)-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for beta(2)Arg16Gly and beta(2)Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly beta(2)-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1 hourly: 2.6 hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6 hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8 hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to beta (2)-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways.


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CRRD Object Information
CRRD ID: 4145096
Created: 2010-10-25
Species: All species
Last Modified: 2010-10-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.