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Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.

Authors: Su, D  Zhang, X  Sui, H  Lu, F  Jin, L  Zhang, J 
Citation: Su D, etal., BMC Med Genet. 2008 Sep 9;9:82.
Pubmed: (View Article at PubMed) PMID:18778489
DOI: Full-text: DOI:10.1186/1471-2350-9-82

BACKGROUND: Rhinitis and asthma are very common diseases involving genetic and environmental factors. Most patients with asthma also have rhinitis, which suggests the concept of 'one airway, one disease.' A disintegrin and metalloproteinase 33 (ADAM33) is the first asthma-susceptible gene to be discovered by positional cloning. To evaluate the potential influence of ADAM33 gene polymorphisms on allergic rhinitis (AR) and allergic asthma (AS), a case-control study was conducted on the Han population of northeast China. METHODS: Six polymorphic sites (V4, T+1, T2, T1, S1, and Q-1) were genotyped in 128 patients with AR, 181 patients with AS, and 151 healthy controls (CTR). Genotypes were determined by the polymerase chain restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed using the chi-square test with Haploview software. RESULTS: The single nucleotide polymorphisms (SNPs), V4 G/C, T+1 A/G, and T1 G/A, of the ADAM33 gene may be the causal variants in AR, whereas ADAM33 V4 G/C, T2 A/G, T1 G/A, and Q-1A/G may participate in the susceptibility of AS. CONCLUSION: These results suggest that polymorphisms of the ADAM33 gene may modify individual susceptibility to AR and AS in a Chinese Han population.

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CRRD Object Information
CRRD ID: 4145378
Created: 2010-11-02
Species: All species
Last Modified: 2010-11-02
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.