Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma.

Authors: Jungraithmayr, W  Frings, C  Zissel, G  Prasse, A  Passlick, B  Stoelben, E 
Citation: Jungraithmayr W, etal., Respirology. 2008 Nov;13(7):1022-7. Epub 2008 Aug 26.
Pubmed: (View Article at PubMed) PMID:18764914
DOI: Full-text: DOI:10.1111/j.1440-1843.2008.01391.x

BACKGROUND AND OBJECTIVE: Pulmonary resection may cause inflammatory changes with subsequent injury to the remaining lung and deterioration in respiratory function. This study investigated the pattern of serum inflammatory markers and exhaled breath condensate (EBC) in patients undergoing major lung resection due to bronchial carcinoma compared with minimally invasive thoracic surgery. METHODS: The pro-inflammatory markers IL-1-beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured preoperatively (day -1) and on three postoperative days (day 1, 3, 7) in serum and EBC in patients after lobectomy or pneumonectomy due to bronchial carcinoma (test group) and in patients undergoing thoracoscopy with minimal wedge resection (control group). RESULTS: All mediators were detectable in serum and all but IL-8 were detectable in EBC. No patient suffered postoperative respiratory failure. In the test group, serum IL-6 was significantly higher postoperatively compared with day -1 (P < 0.001). For EBC (test group), the postoperative values of IL-1-beta were significantly higher compared with day -1 (P = 0.005). In EBC (test group), day -1 TNF-alpha and sICAM-1 were significantly higher compared with controls (P < 0.029 and P = 0.032, respectively). There was no correlation between the levels of mediators and the extent of resection. CONCLUSIONS: Pro-inflammatory markers are detected in EBC following pulmonary surgery. Mediators are detectable in both serum and EBC in patients with bronchial carcinoma undergoing pulmonary resection, but the levels are higher in EBC.


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CRRD Object Information
CRRD ID: 4145523
Created: 2010-11-08
Species: All species
Last Modified: 2010-11-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.