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[Association of interleukin-13 gene polymorphisms with atopic bronchial asthma]

Authors: Dmitrieva-Zdorova, EV  Voron'ko, OE  Aksenova, MG  Bodoev, NV 
Citation: Dmitrieva-Zdorova EV, etal., Genetika. 2010 Jan;46(1):111-7.
Pubmed: (View Article at PubMed) PMID:20198887

A comparative analysis of allele and genotype distribution of C(-1055)T and R130Q IL13 gene polymorphisms has been performed in Russian patients from the Moscow region. In the study, 283 DNA specimens of atopic bronchial asthma (BA) patients and 227 DNA specimens of healthy donors were used. No association of these markers with ABA development as well as with total IgE concentration has been found. Haplotype frequency analysis did not reveal significant difference between samples. However, significant association ofC(-1055)Tpolymorphism with the disease severity has been revealed (OR = 2.39, 95% confidence interval 1.44-3.98, p = 0.001). Therefore, C(-1055)T polymorphism was shown to be associated with atopic BA progression.


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CRRD Object Information
CRRD ID: 4145593
Created: 2010-11-10
Species: All species
Last Modified: 2010-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.