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Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

Authors: Battle, NC  Choudhry, S  Tsai, HJ  Eng, C  Kumar, G  Beckman, KB  Naqvi, M  Meade, K  Watson, HG  Lenoir, M  Burchard, EG  Burchard, Esteban Gonz├ílez 
Citation: Battle NC, etal., Am J Respir Crit Care Med. 2007 May 1;175(9):881-7. Epub 2007 Feb 15.
Pubmed: (View Article at PubMed) PMID:17303794
DOI: Full-text: DOI:10.1164/rccm.200607-992OC

RATIONALE: Genes in the interleukin (IL)-4/IL-13/IL-4Ralpha pathway have been shown to be associated with asthma and related phenotypes in some populations, but not in others. Furthermore, interaction between these genes has been shown to affect asthma in white and Chinese populations. OBJECTIVES: To determine whether there are IL-4/IL-13 and IL-4Ralpha gene-gene interactions that are associated with asthma in African Americans. METHODS: Eighteen single-nucleotide polymorphisms (SNPs) in IL-4, IL-13, and IL-4Ralpha genes were genotyped in 264 African Americans with asthma and 176 healthy control subjects. We tested the SNPs for genetic associations and gene-gene interactions with asthma, baseline lung function, bronchodilator drug response, and total serum IgE levels. MEASUREMENTS AND MAIN RESULTS: We identified 94 SNPs in IL-4, IL-13, and IL-4Ralpha genes by directly sequencing these genes in 24 African-American subjects with asthma. Seventeen SNPs were analyzed for association with asthma and related phenotypes. We found no evidence of association in the IL-4 gene. One SNP in the IL-13 gene (A-646G, rs2069743) and two SNPs in the IL-4Ralpha gene (A+4679G, rs1805010, and C+22656T, rs1805015) showed association with lung function (both baseline and post-bronchodilator). Although the association between individual SNPs and asthma-related phenotypes differed from previous studies performed in white and Chinese populations, significant gene-gene interaction was found between the IL-13 (A-646G) and IL-4Ralpha (A+4679G) SNPs for baseline lung function among African-American subjects with asthma. CONCLUSIONS: Gene-gene interaction between the IL-13 and IL-4Ralpha genes may play an important role in asthma among African Americans.


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CRRD Object Information
CRRD ID: 4146241
Created: 2010-11-16
Species: All species
Last Modified: 2010-11-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.