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Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis.

Authors: Kim, JJ  Min, JY  Lee, JH 
Citation: Kim JJ, etal., Eur Arch Otorhinolaryngol. 2007 Apr;264(4):395-9. Epub 2006 Nov 8.
Pubmed: (View Article at PubMed) PMID:17091279
DOI: Full-text: DOI:10.1007/s00405-006-0204-x

The IL-4 receptor (IL-4R) and IL-13 genes are candidate genes in atopic diseases. The IL-4Ralpha chain and IL-13 promoter polymorphisms are gain-of-function mutations associated with atopy. We tested whether polymorphisms in the IL-4Ralpha chain and the coding region of the IL-13 gene are associated with allergic rhinitis in a Korean population. Polymerase chain reaction-based assays for IL-4Ralpha Gln551Arg and IL-13 exon 4 G2044A were used for genotyping. There were no differences in the frequencies of the genotypes and alleles of IL-4Ralpha between the controls and patients. The frequency of the IL-13 exon 4 2044A allele was statistically different between the controls and patients. Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Ralpha Gln551Arg polymorphism is not related to allergic rhinitis.


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CRRD Object Information
CRRD ID: 4152796
Created: 2010-11-16
Species: All species
Last Modified: 2010-11-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.