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Expression of tenascin-C long isoforms is induced in the hypothalamus by FGF-1.

Authors: Suzuki, S  Li, AJ  Ikemoto, M  Imamura, T 
Citation: Suzuki S, etal., Neuroreport. 2002 Jun 12;13(8):1041-5.
Pubmed: (View Article at PubMed) PMID:12060805

Fibroblast growth factor (FGF)-1 modulates various brain functions, such as the hypothalamic control of feeding. In the rat, we examined the effect of intracerebroventricularly infused FGF-1 on the hypothalamic expression of tenascin-C, a selective mediator of neuron-glial interaction. In situ hybridization revealed little tenascin-C mRNA expression in control brains, but greatly increased expression in ependymal cells around the third ventricle in the FGF-1-infused rats. Reverse transcription-linked PCR analysis of hypothalamic mRNA revealed an FGF-1-induced expression not of the shortest isoform of tenascin-C, but of the long isoforms (with additional fibronectin type III-domain insertions). Quantitative analysis by real time PCR revealed that this induction was transient and dose-dependent. Specific modulation of hypothalamic neuron-glial interactions by tenascin-C may mediate FGF-1-induced feeding suppression.


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CRRD Object Information
CRRD ID: 4889617
Created: 2010-12-07
Species: All species
Last Modified: 2010-12-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.