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Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study.

Authors: Saadi, A  Gao, G  Li, H  Wei, C  Gong, Y  Liu, Q 
Citation: Saadi A, etal., BMC Med Genet. 2009 Jul 21;10:71.
Pubmed: (View Article at PubMed) PMID:19622139
DOI: Full-text: DOI:10.1186/1471-2350-10-71

BACKGROUND: Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Importantly, variants in the VDR gene have been susceptible in the past to raise the risk of asthma in several populations. These effects of VDR allelic markers remain speculative in the Chinese Han population. RESULTS: A case-control study of 1090 individuals including 567 asthmatic patients was realized on five SNPs within the VDR gene. Only rs7975232 (ApaI) marker showed a significant association with asthma (P = 0.009). Haplotype analysis of the five VDR polymorphisms showed a significant association with asthma (global-p value = 0.012). CONCLUSION: Although the susceptibility of VDR gene variants with asthma could not be confirmed for all SNPs tested in this study, the significant association obtained for rs7975232 provides evidence for a previously unknown report about the Chinese Han population and may raise the susceptibility of VDR to be a candidate gene for asthma.


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CRRD Object Information
CRRD ID: 4889868
Created: 2010-12-09
Species: All species
Last Modified: 2010-12-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.