IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4.

Authors: Shandley, S  Martinez, S  Krolick, K 
Citation: Shandley S, etal., Clin Immunol. 2009 Aug;132(2):246-56. Epub 2009 Apr 22.
Pubmed: (View Article at PubMed) PMID:19395316
DOI: Full-text: DOI:10.1016/j.clim.2009.03.523

The study reported below describes increased expression of IL-4 receptor in cultured rat myocytes following exposure to an antibody reactive with the acetylcholine receptor (AChR). In addition, upon up-regulation of IL-4R, myocytes demonstrated an increased responsiveness to IL-4 by producing increased levels of IL-15. Moreover, following passive transfer of AChR antibody into Lewis rats, both the increased IL-4R expression and IL-15 production were also observed in intact skeletal muscle, co-localizing in particular individual muscle fibers; the same muscle fibers also produced the chemokine MCP-1 to which IL-4-producing T cells were attracted. A model is proposed in which these muscle activities participate in disease progression in experimental myasthenia gravis.


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CRRD Object Information
CRRD ID: 4889981
Created: 2010-12-10
Species: All species
Last Modified: 2010-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.