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Asthma susceptible genes in Chinese population: a meta-analysis.

Authors: Li, X  Zhang, Y  Zhang, J  Xiao, Y  Huang, J  Tian, C  He, C  Deng, Y  Yang, Y  Fan, H 
Citation: Li X, etal., Respir Res. 2010 Sep 24;11:129.
Pubmed: (View Article at PubMed) PMID:20868478
DOI: Full-text: DOI:10.1186/1465-9921-11-129

BACKGROUND: Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population. METHODS: The authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications. RESULTS: Seven polymorphisms were found being associated with risk of asthma, namely: A Disintegrin and Metalloprotease 33 (ADAM33) T1-C/T (odds ratio [OR] = 6.07, 95% confidence interval [CI]: 2.69-13.73), Angiotensin-Converting Enzyme (ACE) D/I (OR = 3.85, 95%CI: 2.49-5.94), High-affinity IgE receptor beta chain (FcepsilonRIbeta) -6843G/A (OR = 1.49, 95%CI: 1.01-2.22), Interleukin 13(IL-13) -1923C/T (OR = 2.99, 95%CI: 2.12-4.24), IL-13 -2044A/G (OR = 1.49, 95%CI: 1.07-2.08), Regulated upon Activation, Normal T cell Expressed and Secreted (RANTES) -28C/G (OR = 1.64, 95%CI: 1.09-2.46), Tumor Necrosis Factor-alpha (TNF-alpha) -308G/A(OR = 1.42, 95%CI: 1.09, 1.85). After subgroup analysis by age, the ACE D/I, beta2-Adrenergic Receptor (beta2-AR) -79G/C, TNF-alpha -308G/A, Interleukin 4 receptor(IL-4R) -1902G/A and IL-13 -1923C/T polymorphisms were found significantly associated with asthma risk in Chinese children. In addition, the ACE D/I, FcepsilonRIbeta -6843G/A, TNF-alpha -308G/A, IL-13 -1923C/T and IL-13 -2044A/G polymorphisms were associated with asthma risk in Chinese adults. CONCLUSION: ADAM33, FcepsilonRIbeta, RANTES, TNF-alpha, ACE, beta2-AR, IL-4R and IL-13 genes could be proposed as asthma susceptible genes in Chinese population. Given the limited number of studies, more data are required to validate these associations.


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CRRD Object Information
CRRD ID: 4890387
Created: 2010-12-16
Species: All species
Last Modified: 2010-12-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.