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5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.

Authors: Torres-Galvan, SM  Cumplido, JA  Buset, N  Caballero-Hidalgo, A  Blanco, C  Hernandez, E  Carrillo, T 
Citation: Torres-Galvan SM, etal., J Investig Allergol Clin Immunol. 2009;19(6):453-8.
Pubmed: (View Article at PubMed) PMID:20128419

BACKGROUND: Cysteinyl-leukotrienes are mediators of inflammatory responses in bronchial asthma. We studied the genes encoding the enzymes involved in their synthesis to identify risk factors for asthma. The promoter polymorphisms LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 have been reported to be associated with bronchial asthma. METHODS: We analyzed the effects of LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 on asthma susceptibility by means of a case-control study with 193 ethnically matched, unrelated individuals. Participants were classified as severe asthmatics, nonsevere asthmatics, and nonasthmatics, using a combination of 2 techniques: polymerase chain reaction-restricted fragment length polymorphism and multiplex capillary electrophoresis. RESULTS: No association was found between these polymorphisms and asthma, neither individually nor in combination. CONCLUSION: Although the studied polymorphisms have been previously reported to constitute risk factors for the disease, we found no association between LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 polymorphisms and bronchial asthma.


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CRRD Object Information
CRRD ID: 4890407
Created: 2010-12-16
Species: All species
Last Modified: 2010-12-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.