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A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.

Authors: Bai, C  Matsui, E  Ohnishi, H  Kimata, K  Kasahara, K  Kaneko, H  Kato, Z  Fukao, T  Kondo, N 
Citation: Bai C, etal., Int J Mol Med. 2008 Feb;21(2):139-44.
Pubmed: (View Article at PubMed) PMID:18204779

Cysteinyl-leukotrienes are important pro-inflammatory mediators in bronchial asthma (BA) and are derived from arachidonic acid by the action of 5-lipoxygenase. We identified a novel polymorphism, c.760 G>A (E254K), in exon 6 of the 5-lipoxygenase gene (5-LO). This substitution was detected in 11 out of 180 patients with BA, but not in any of the 150 non-allergic subjects. The frequency of c.760 G>A showed a significant difference between BA and non-allergic subjects (P=0.0007). The c.760 G>A polymorphism existed at the surface edge of the C-terminal catalytic domain, and the E-to-K substitution changed the charge of the side chain from negative to positive. Thus, our results suggest that E254K in the 5-LO might be associated with BA.


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CRRD Object Information
CRRD ID: 4890410
Created: 2010-12-16
Species: All species
Last Modified: 2010-12-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.