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Role for macrophage migration inhibitory factor in asthma.

Authors: Mizue, Y  Ghani, S  Leng, L  McDonald, C  Kong, P  Baugh, J  Lane, SJ  Craft, J  Nishihira, J  Donnelly, SC  Zhu, Z  Bucala, R 
Citation: Mizue Y, etal., Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14410-5. Epub 2005 Sep 26.
Pubmed: (View Article at PubMed) PMID:16186482
DOI: Full-text: DOI:10.1073/pnas.0507189102

Macrophage migration inhibitory factor (MIF) is an immunologic regulator that is expressed in inflammatory and autoimmune disorders. We investigated MIF's role in asthma using genetic approaches in a mouse model and in a cohort of asthma patients. Mice genetically deficient in MIF that were primed and aerosol-challenged with ovalbumin showed less pulmonary inflammation and lower airway hyperresponsiveness than genetically matched, wild-type controls. MIF deficiency also resulted in lower titers of specific IgE, IgG(1), and IgG(2a), and decreased pulmonary, T(H)2 cytokine levels. IL-5 concentrations were lower and corresponded to decreased eosinophil numbers in bronchoalveolar lavage fluid. T cell studies also showed a lower level of antigen-specific responses in MIF-KO versus wild-type mice. In an analysis of 151 white patients with mild, moderate, or severe asthma (Global Initiative for Asthma criteria), a significant association was found between mild asthma and the low-expression, 5-CATT MIF allele. Pharmacologic inhibition of MIF may be beneficial and could be guided by the MIF genotype of affected individuals.


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CRRD Object Information
CRRD ID: 4891052
Created: 2011-01-04
Species: All species
Last Modified: 2011-01-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.