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Plasma brain-derived neurotrophic factor levels are associated with clinical severity in school age children with asthma.

Authors: Muller, GC  Pitrez, PM  Teixeira, AL  Pires, PS  Jones, MH  Stein, RT  Bauer, ME 
Citation: Muller GC, etal., Clin Exp Allergy. 2010 Dec;40(12):1755-9. doi: 10.1111/j.1365-2222.2010.03618.x. Epub 2010 Sep 28.
Pubmed: (View Article at PubMed) PMID:20874832
DOI: Full-text: DOI:10.1111/j.1365-2222.2010.03618.x

BACKGROUND: Asthma is characterized by chronic inflammation of the airways with significant changes in leucocyte trafficking, cellular activation and tissue remodelling. Brain-derived neurotrophic factor (BDNF) has been involved with asthma and allergic diseases but its role as a severity marker in paediatric asthma has not been clinically assessed. OBJECTIVES: To evaluate plasma BDNF and inflammatory markers in order to address their relationships with disease severity in children (6-15 years) with controlled persistent asthma. METHODS: Children with persistent asthma were selected and lung function and skin prick tests were performed in all patients. Plasma BDNF levels and various inflammatory markers (CCL3, CCL11, CCL22, CCL24, CXCL8, CXCL9, CXCL10, soluble TNF receptors) were assessed by ELISAs. RESULTS: Subjects with moderate and severe asthma had higher BDNF levels than mild asthma and controls (P<0.001). The chemokines studied and soluble TNF receptors did not differ between the studied groups. CONCLUSION AND CLINICAL RELEVANCE: Our results indicate BDNF as a potential biomarker for clinical severity in children with asthma.

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CRRD Object Information
CRRD ID: 4891063
Created: 2011-01-04
Species: All species
Last Modified: 2011-01-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.