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CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung.

Authors: Mionnet, C  Buatois, V  Kanda, A  Milcent, V  Fleury, S  Lair, D  Langelot, M  Lacoeuille, Y  Hessel, E  Coffman, R  Magnan, A  Dombrowicz, D  Glaichenhaus, N  Julia, V 
Citation: Mionnet C, etal., Nat Med. 2010 Nov;16(11):1305-12. Epub 2010 Oct 31.
Pubmed: (View Article at PubMed) PMID:21037587
DOI: Full-text: DOI:10.1038/nm.2253

Allergic asthma is a T helper type 2 (T(H)2)-dominated disease of the lung. In people with asthma, a fraction of CD4(+) T cells express the CX3CL1 receptor, CX3CR1, and CX3CL1 expression is increased in airway smooth muscle, lung endothelium and epithelium upon allergen challenge. Here we found that untreated CX3CR1-deficient mice or wild-type (WT) mice treated with CX3CR1-blocking reagents show reduced lung disease upon allergen sensitization and challenge. Transfer of WT CD4(+) T cells into CX3CR1-deficient mice restored the cardinal features of asthma, and CX3CR1-blocking reagents prevented airway inflammation in CX3CR1-deficient recipients injected with WT T(H)2 cells. We found that CX3CR1 signaling promoted T(H)2 survival in the inflamed lungs, and injection of B cell leukemia/lymphoma-2 protein (BCl-2)-transduced CX3CR1-deficient T(H)2 cells into CX3CR1-deficient mice restored asthma. CX3CR1-induced survival was also observed for T(H)1 cells upon airway inflammation but not under homeostatic conditions or upon peripheral inflammation. Therefore, CX3CR1 and CX3CL1 may represent attractive therapeutic targets in asthma.


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CRRD Object Information
CRRD ID: 4891882
Created: 2011-01-19
Species: All species
Last Modified: 2011-01-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.