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CX3CR1 polymorphisms are associated with atopy but not asthma in German children.

Authors: Depner, M  Kormann, MS  Klopp, N  Illig, T  Vogelberg, C  Weiland, SK  Von Mutius, E  Combadiere, C  Kabesch, M 
Citation: Depner M, etal., Int Arch Allergy Immunol. 2007;144(1):91-4. Epub 2007 May 15.
Pubmed: (View Article at PubMed) PMID:17505143
DOI: Full-text: DOI:10.1159/000102620

Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation. Two common, nonsynonymous polymorphisms in CX3CR1 have previously been shown to alter the function of the CX3CL1/CX3CR1 pathway and were suggested to modify the risk for asthma. Using matrix-assisted laser desorption/ionization time-of-flight technology, we genotyped polymorphisms Val249Ile and Thr280Met in a cross-sectional population of German children from Munich (n = 1,159) and Dresden (n = 1,940). For 249Ile an odds ratio of 0.77 (95% confidence interval 0.63-0.96; p = 0.017) and for 280Met an odds ratio of 0.71 (95% confidence interval 0.56-0.89; p = 0.004) were found with atopy in Dresden but not in Munich. Neither polymorphism was associated with asthma. Thus, amino acid changes in CX3CR1 may influence the development of atopy but not asthma in German children. Potentially, other factors such as environmental effects may modify the role of CX3CR1 polymorphisms.


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CRRD Object Information
CRRD ID: 4891904
Created: 2011-01-19
Species: All species
Last Modified: 2011-01-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.