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Characterization of a common susceptibility locus for asthma-related traits.

Authors: Laitinen, T  Polvi, A  Rydman, P  Vendelin, J  Pulkkinen, V  Salmikangas, P  Makela, S  Rehn, M  Pirskanen, A  Rautanen, A  Zucchelli, M  Gullsten, H  Leino, M  Alenius, H  Petays, T  Haahtela, T  Laitinen, A  Laprise, C  Hudson, TJ  Laitinen, LA  Kere, J 
Citation: Laitinen T, etal., Science. 2004 Apr 9;304(5668):300-4.
Pubmed: (View Article at PubMed) PMID:15073379
DOI: Full-text: DOI:10.1126/science.1090010

Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein-coupled receptor named GPRA (G protein-coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and asthmatic individuals. In three cohorts from Finland and Canada, single nucleotide polymorphism-tagged haplotypes associated with high serum immunoglobulin E or asthma. The murine ortholog of GPRA was up-regulated in a mouse model of ovalbumin-induced inflammation. Together, these data implicate GPRA in the pathogenesis of atopy and asthma.


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CRRD Object Information
CRRD ID: 4891921
Created: 2011-01-21
Species: All species
Last Modified: 2011-01-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.