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Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group.

Authors: Djidjik, R  Ghaffor, M  Brun, M  Gharnaout, M  Salah, SS  Boukouaci, W  Djidjik, H  Benyounes, A  Koumaravelou, K  Krishnamoorthy, R  Abbadi, MC  Charron, D  Tamouza, R 
Citation: Djidjik R, etal., Tissue Antigens. 2008 Feb;71(2):160-4. Epub 2007 Dec 13.
Pubmed: (View Article at PubMed) PMID:18086269
DOI: Full-text: DOI:10.1111/j.1399-0039.2007.00976.x

Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin-dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 -84 G-->A and NOS3 -786 T-->C, 894 G-->T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the -786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the 'ab' genotype of the 27-bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders.

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CRRD Object Information
CRRD ID: 4892054
Created: 2011-01-31
Species: All species
Last Modified: 2011-01-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.