Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group.

Authors: Djidjik, R  Ghaffor, M  Brun, M  Gharnaout, M  Salah, SS  Boukouaci, W  Djidjik, H  Benyounes, A  Koumaravelou, K  Krishnamoorthy, R  Abbadi, MC  Charron, D  Tamouza, R 
Citation: Djidjik R, etal., Tissue Antigens. 2008 Feb;71(2):160-4. Epub 2007 Dec 13.
Pubmed: (View Article at PubMed) PMID:18086269
DOI: Full-text: DOI:10.1111/j.1399-0039.2007.00976.x

Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin-dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 -84 G-->A and NOS3 -786 T-->C, 894 G-->T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the -786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the 'ab' genotype of the 27-bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders.


Disease Annotations
Phenotype Annotations
Objects Annotated

Additional Information

CRRD Object Information
CRRD ID: 4892054
Created: 2011-01-31
Species: All species
Last Modified: 2011-01-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.