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Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

Authors: Walker, JK  Ahumada, A  Frank, B  Gaspard, R  Berman, K  Quackenbush, J  Schwartz, DA 
Citation: Walker JK, etal., Am J Respir Cell Mol Biol. 2006 Jun;34(6):711-8. Epub 2006 Feb 10.
Pubmed: (View Article at PubMed) PMID:16474097
DOI: Full-text: DOI:10.1165/rcmb.2005-0314OC

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of "asthma."


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CRRD Object Information
CRRD ID: 4892093
Created: 2011-02-04
Species: All species
Last Modified: 2011-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.