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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control.

Authors: Strickland, DH  Judd, S  Thomas, JA  Larcombe, AN  Sly, PD  Holt, PG 
Citation: Strickland DH, etal., Mucosal Immunol. 2011 Jan;4(1):43-52. Epub 2010 Jul 28.
Pubmed: (View Article at PubMed) PMID:20668438
DOI: Full-text: DOI:10.1038/mi.2010.43

The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. This is preceded by upregulation of CD86 on resident airway dendritic cells (DCs) that normally lack competence in T-cell triggering. Moreover, AHR duration is controlled via T-regulatory (Treg) cells, which can attenuate CD86 upregulation on DC. We show that airway mucosal Treg/DC interaction represents an accessible therapeutic target for asthma control. Notably, baseline airway Treg activity in sensitized rats can be boosted by microbe-derived stimulation of the gut, resulting in enhanced capacity to control CD86 expression on airway DC triggered by aeroallergen and accelerated resolution of AHR.


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CRRD Object Information
CRRD ID: 4892199
Created: 2011-02-10
Species: All species
Last Modified: 2011-02-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.