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Positional cloning of a novel gene influencing asthma from chromosome 2q14.

Authors: Allen, M  Heinzmann, A  Noguchi, E  Abecasis, G  Broxholme, J  Ponting, CP  Bhattacharyya, S  Tinsley, J  Zhang, Y  Holt, R  Jones, EY  Lench, N  Carey, A  Jones, H  Dickens, NJ  Dimon, C  Nicholls, R  Baker, C  Xue, L  Townsend, E  Kabesch, M  Weiland, SK  Carr, D  Von Mutius, E  Adcock, IM  Barnes, PJ  Lathrop, GM  Edwards, M  Moffatt, MF  Cookson, WO 
Citation: Allen M, etal., Nat Genet. 2003 Nov;35(3):258-63. Epub 2003 Oct 19.
Pubmed: (View Article at PubMed) PMID:14566338
DOI: Full-text: DOI:10.1038/ng1256

Asthma is a common disease in children and young adults. Four separate reports have linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 (refs. 1-4), and two mouse genome screens have linked bronchial hyper-responsiveness to the region homologous to 2q14 (refs. 5,6). We found and replicated association between asthma and the D2S308 microsatellite, 800 kb distal to the IL1 cluster on 2q14. We sequenced the surrounding region and constructed a comprehensive, high-density, single-nucleotide polymorphism (SNP) linkage disequilibrium (LD) map. SNP association was limited to the initial exons of a solitary gene of 3.6 kb (DPP10), which extends over 1 Mb of genomic DNA. DPP10 encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy.


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CRRD Object Information
CRRD ID: 4892276
Created: 2011-02-16
Species: All species
Last Modified: 2011-02-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.