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House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells.

Authors: Hongjia, L  Qingling, G  Meiying, L  Weixuan, W  Lihong, Z  Yongsheng, G  Yanli, L  Jinxiang, W  Liang, D 
Citation: Hongjia L, etal., Cell Biochem Funct. 2010 Oct;28(7):597-603.
Pubmed: (View Article at PubMed) PMID:20941750
DOI: Full-text: DOI:10.1002/cbf.1697

Aberrant innate and adaptive immune responsed to allergens and environmental pollutants lead to respiratory allergic disease such as asthma. In this study, we focused on toll-like receptor-4 (TLR4) expressed on airway epithelium to identify house dust mite (HDM)-regulated allergic inflammation via TLR4 signaling pathway and the triggering to alveolar macrophages (AM)-driven adaptive immune response. The authors found that mouse exposed to HDM showed more eosinophils, neutrophils, monocytes, lymphocytes as well as total cells in bronchoalveolar lavage fluid (BALF) confirmed by flow cytometry. Besides, the expression of TLR4 in airway epithelial cells was significantly increased in both mRNA and protein levels in mice treated with HDM and the expression of CD40 and CD86 in AM was also increased in mice exposed to HDM. Tight correlation between TLR4 protein and CD40, CD86 in AM was identified. This study demonstrates that TLR4 expression on airway epithelium played an essential role in HDM-induced activation of AM in immune responses and allergic inflammation. The airway epithelial TLR4 signaling pathway revealed tight connection between endotoxin exposure and asthma prevalence in the clinic.


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CRRD Object Information
CRRD ID: 4892277
Created: 2011-02-16
Species: All species
Last Modified: 2011-02-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.