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Regulation of expression and function of dipeptidyl peptidase 4 (DP4), DP8/9, and DP10 in allergic responses of the lung in rats.

Authors: Schade, J  Stephan, M  Schmiedl, A  Wagner, L  Niestroj, AJ  Demuth, HU  Frerker, N  Klemann, C  Raber, KA  Pabst, R  Von Horsten, S 
Citation: Schade J, etal., J Histochem Cytochem. 2008 Feb;56(2):147-55. Epub 2007 Oct 29.
Pubmed: (View Article at PubMed) PMID:17967935
DOI: Full-text: DOI:10.1369/jhc.7A7319.2007

The expression of dipeptidyl peptidase 4 (DP4, CD26) affects T-cell recruitment to lungs in an experimental rat asthma model. Furthermore, the gene of the structural homologous DP10 represents a susceptibility locus for asthma in humans, and the functional homologous DP8/9 are expressed in human leukocytes. Thus, although several mechanisms may account for a role of DP4-like peptidases in asthma, detailed information on their anatomical sites of expression and function in lungs is lacking. Therefore, bronchi and lung parenchyma were evaluated using immunohistochemistry and histochemical/enzymatic activity assays, as well as quantitative real-time PCR for this family of peptidases in naive and asthmatic rat lungs derived from wild-type F344 and DP4-deficient F344 rat strains. Surprisingly, results show not only that the induction of experimental asthma increases DP4 enzymatic activity in the bronchoalveolar lavage fluid and parenchyma, but also that DP8/9 enzymatic activity is regulated and, as well as the expression of DP10, primarily found in the bronchial epithelium of the airways. This is the first report showing a differential and site-specific DP4-like expression and function in the lungs, suggesting a pathophysiologically significant role in asthma.

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CRRD Object Information
CRRD ID: 4892278
Created: 2011-02-16
Species: All species
Last Modified: 2011-02-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.