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Up-regulation of protease-activated receptor 2 in allergic rhinitis.

Authors: Lee, HM  Kim, HY  Kang, HJ  Woo, JS  Chae, SW  Lee, SH  Hwang, SJ 
Citation: Lee HM, etal., Ann Otol Rhinol Laryngol. 2007 Jul;116(7):554-8.
Pubmed: (View Article at PubMed) PMID:17727088

OBJECTIVES: We compared the patterns of PAR-2 messenger RNA (mRNA) and protein expression in the nasal mucosa of subjects with and without allergic rhinitis. METHODS: Biopsy specimens were obtained from 10 patients with allergic rhinitis and 10 normal controls. RNA was extracted from the nasal mucosa, and semiquantitative reverse transcription-polymerase chain reaction was performed for PAR-2. Tissue sections were immunostained for PAR-2 by use of specific antibody. RESULTS: The expression levels of PAR-2 mRNA in allergic rhinitis nasal mucosa were significantly up-regulated as compared with those in normal nasal mucosa. PAR-2 immunoreactivity was observed in the epithelium and submucosal glands in both normal controls and subjects with allergic rhinitis. Stronger immunoreactivity for PAR-2 was observed in allergic rhinitis nasal mucosa as compared with normal nasal mucosa. CONCLUSIONS: These results suggest that PAR-2 may be involved in allergic nasal inflammation.

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CRRD Object Information
CRRD ID: 4892590
Created: 2011-02-24
Species: All species
Last Modified: 2011-02-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.