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Overexpression of glucocorticoid receptor-beta in severe allergic rhinitis.

Authors: Ishida, A  Ohta, N  Koike, S  Aoyagi, M  Yamakawa, M 
Citation: Ishida A, etal., Auris Nasus Larynx. 2010 Oct;37(5):584-8. Epub 2010 Feb 24.
Pubmed: (View Article at PubMed) PMID:20185258
DOI: Full-text: DOI:10.1016/j.anl.2009.12.002

OBJECTIVE: To clarify the role of glucocorticoid receptor-beta in resistance to glucocorticoid therapy for allergic rhinitis, we studied 37 tissue samples from 20 patients with severe allergic rhinitis, and samples from age-matched controls. METHODS: Patients were treated with intranasal fluticasone for 6 months and inferior turbinectomy was performed for patients with poor response to glucocorticoid treatment. The expression of glucocorticoid receptor-alpha (GR-alpha), glucocorticoid receptor-beta (GR-beta), and nuclear factor-kappaB (NF-kappaB) in nasal mucosa was studied immunohistochemically. RESULTS: GR-alpha and NF-kappaB were expressed to a similar extent in patients and controls, but GR-beta was expressed significantly more in patients, resulting in an increased GR-beta/GR-alpha ratio. CONCLUSION: Our findings suggest that GR-beta plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis.


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CRRD Object Information
CRRD ID: 4892593
Created: 2011-02-24
Species: All species
Last Modified: 2011-02-24
Status: ACTIVE


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