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Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: association study with atopic asthma in the Japanese population.

Authors: Ahmed, S  Ihara, K  Sasaki, Y  Nakao, F  Nishima, S  Fujino, T  Hara, T 
Citation: Ahmed S, etal., Exp Clin Immunogenet. 2000;17(1):18-22.
Pubmed: (View Article at PubMed) PMID:10686479
DOI: Full-text: DOI:19120

Interleukin (IL)-4 and IL-13 play key roles in the development of atopic asthma. The IL-13 receptor (R) alpha' chain is a component of both IL-4R and IL-13R complexes. By screening the whole coding region of the IL-13Ralpha' gene for polymorphisms, we identified a new polymorphism at nucleotide position 1050 from the ATG start codon. The allelic frequency of the C/T polymorphism in the Japanese population was found to be 0.97:0.03. Because of the low frequency of the T allele, the association study failed to indicate any significant association between this polymorphism and atopic asthma in the Japanese population. Further studies are required in other racial groups with higher frequencies of this polymorphism to elucidate the association.

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CRRD Object Information
CRRD ID: 4892655
Created: 2011-02-28
Species: All species
Last Modified: 2011-02-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.