Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.

Authors: Zhu, Z  Zheng, T  Homer, RJ  Kim, YK  Chen, NY  Cohn, L  Hamid, Q  Elias, JA 
Citation: Zhu Z, etal., Science. 2004 Jun 11;304(5677):1678-82.
Pubmed: (View Article at PubMed) PMID:15192232
DOI: Full-text: DOI:10.1126/science.1095336

Chitin is a surface component of parasites and insects, and chitinases are induced in lower life forms during infections with these agents. Although chitin itself does not exist in humans, chitinases are present in the human genome. We show here that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)-specific, interleukin-13 (IL-13)-mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma. AMCase neutralization ameliorated Th2 inflammation and airway hyperresponsiveness, in part by inhibiting IL-13 pathway activation and chemokine induction. AMCase may thus be an important mediator of IL-13-induced responses in Th2-dominated disorders such as asthma.

Annotation

Disease Annotations
Objects Annotated

Additional Information

 
CRRD Object Information
CRRD ID: 4985150
Created: 2011-03-01
Species: All species
Last Modified: 2011-03-01
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.