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Association of asthma with a functional promoter polymorphism in the IL16 gene.

Authors: Burkart, KM  Barton, SJ  Holloway, JW  Yang, IA  Cakebread, JA  Cruikshank, W  Little, F  Jin, X  Farrer, LA  Clough, JB  Keith, TP  Holgate, S  Center, DM  O'Connor, GT 
Citation: Burkart KM, etal., J Allergy Clin Immunol. 2006 Jan;117(1):86-91.
Pubmed: (View Article at PubMed) PMID:16387589
DOI: Full-text: DOI:10.1016/j.jaci.2005.10.011

BACKGROUND: IL-16, a multifunctional cytokine with increased expression in the airways of asthmatic subjects, inhibits allergic airway inflammation in animal models. A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described. OBJECTIVE: We sought to examine the functional significance of this promoter SNP and its relationship to asthma. METHODS: We examined the effect of the -295 SNP on promoter activity in cell-line (HBE4-E6/E7) transfection experiments. We investigated the association of the IL16 -295 genotype with asthma among 341 affected sib-pair white families and 184 unrelated nonasthmatic control subjects. We analyzed the association between the IL16 genotype and asthma using family-based association test and case-control analyses. RESULTS: In in vitro transfection experiments the T allele in the -295 position was associated with substantially reduced promoter activity compared with the C allele. In the family study the more common T allele at the -295 position was significantly associated with all asthma phenotypes (P = .002 to P = .015). In the case-control analysis asthmatic subjects were more likely than unrelated nonasthmatic control subjects to have the -295 TT genotype, but this did not reach statistical significance (odds ratio, 1.36; 95% CI, 0.92-2.02). CONCLUSIONS: The T allele at the -295 position in the IL16 promoter region is associated with reduced promoter activity relative to the C allele and with asthma in this white population. Further investigation is needed to delineate the mechanisms underlying these findings and the relationship of the IL16 -295 genotype to asthma in other populations.


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CRRD Object Information
CRRD ID: 5024934
Created: 2011-03-02
Species: All species
Last Modified: 2011-03-02
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.