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Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors.

Authors: Liebrich, M  Guo, LH  Schluesener, HJ  Schwab, JM  Dietz, K  Will, BE  Meyermann, R 
Citation: Liebrich M, etal., Arch Immunol Ther Exp (Warsz). 2007 Jan-Feb;55(1):41-7.
Pubmed: (View Article at PubMed) PMID:17221335
DOI: Full-text: DOI:10.1007/s00005-007-0003-0

INTRODUCTION: Macrophages/microglial cells are considered as immune cells in the central nervous system. Interleukin (IL)-16 is a proinflammatory cytokine produced by activated monocytic cells. MATERIALS AND METHODS: Expression of IL-16 was analyzed by immunohistochemistry in human astrocytic brain tumors and the rat C6 glioblastoma tumor model. IL-16 was detected in both human astrocytic brain tumors and rat C6 glioma. RESULTS: Compared with human control brains, a significant increase in the percentages of parenchymal IL-16+ macrophages/microglia was observed already in grade II astrocytomas, indicating that IL-16+ immunostaining could be a descriptor of a macrophage/microglia subset in astrocytic brain tumors. A further increase was observed at the transition from grade II to III astrocytomas. This increase in IL-16 immunoreactivity correlated with WHO grades of human astrocytic brain tumors. CONCLUSIONS: Therefore, IL-16 might be a so far unknown factor in the regulation of the local inflammatory milieu of human and experimental astrocytomas.

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CRRD Object Information
CRRD ID: 5024941
Created: 2011-03-02
Species: All species
Last Modified: 2011-03-02
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.