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Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma.

Authors: Wang, G  Lu, J 
Citation: Wang G and Lu J, Sci China Life Sci. 2010 Oct;53(10):1215-20. Epub 2010 Oct 17.
Pubmed: (View Article at PubMed) PMID:20953944
DOI: Full-text: DOI:10.1007/s11427-010-4067-4

This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.


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CRRD Object Information
CRRD ID: 5128514
Created: 2011-03-07
Species: All species
Last Modified: 2011-03-07
Status: ACTIVE


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