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Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma.

Authors: Andersson, CK  Bergqvist, A  Mori, M  Mauad, T  Bjermer, L  Erjefalt, JS 
Citation: Andersson CK, etal., J Allergy Clin Immunol. 2011 Mar 7.
Pubmed: (View Article at PubMed) PMID:21388666
DOI: Full-text: DOI:10.1016/j.jaci.2011.01.022

BACKGROUND: A significant proportion of patients with asthma have persistent symptoms despite treatment with inhaled glucocorticosteroids. OBJECTIVE: We hypothesized that in these patients, the alveolar parenchyma is subjected to mast cell-associated alterations. METHODS: Bronchial and transbronchial biopsies from healthy controls (n = 8), patients with allergic rhinitis (n = 8), and patients with atopic uncontrolled asthma (symptoms despite treatment with inhaled glucocorticosteroids; mean dose, 743 mug/d; n = 14) were processed for immunohistochemical identification of mast cell subtypes and mast cell expression of FcepsilonRI and surface-bound IgE. RESULTS: Whereas no difference in density of total bronchial mast cells was observed between patients with asthma and healthy controls, the total alveolar mast cell density was increased in the patients with asthma (P < .01). Division into mast cell subtypes revealed that in bronchi of patients with asthma, tryptase positive mast cells (MC(T)) numbers decreased compared with controls (P


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CRRD Object Information
CRRD ID: 5128711
Created: 2011-03-15
Species: All species
Last Modified: 2011-03-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.