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ADA polymorphisms and asthma: a study in the Chinese Han population.

Authors: Liu, Y  Saccucci, P  Qi, H  Wu, HC  Zhao, F  Dai, Y  Bottini, N  Gloria-Bottini, F 
Citation: Liu Y, etal., J Asthma. 2006 Apr;43(3):203-6.
Pubmed: (View Article at PubMed) PMID:16754522
DOI: Full-text: DOI:10.1080/02770900600566827

We have studied a sample of 120 asthmatic patients and 116 healthy control subjects from the Chinese Han population. Three polymorphic sites: ADA(1), ADA(2), and ADA(6), within the ADA gene have been examined. The proportion of carriers of *2 allele at locus ADA(1) is drastically reduced in asthmatics as compared to controls. There is an epistatic interaction of ADA(2) on the ADA(1) site characterized by a suppressive effect by the *2 allele of ADA(2) on the protective effect exerted by the *2 allele of ADA(1) site on susceptibility to asthma. Our data suggest the presence of some DNA sequences influencing the susceptibility to asthma are located in the area between ADA(1) and ADA(2) sites.


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CRRD Object Information
CRRD ID: 5128848
Created: 2011-03-21
Species: All species
Last Modified: 2011-03-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.